Het-PDB Navi2 (PDB: 6H5C)

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Ligands
Code	Name		Style	Show	Link
FSQ	(1~{S},3~{R},4~{S},5~{R})-3-methyl-3,4,5-tris(hydroxyl)cyclohexane-1-carboxylic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Modification
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Download interaction data: 6H5C

Code :

6H5C PDBj RCSB PDB PDBe

Header :

LYASE

Title :

Crystal structure of DHQ1 from Salmonella typhi covalently modified by ligand 1

Release Data :

2019-07-24

Compound :

mol_id	molecule	chains	synonym
1	3-dehydroquinate dehydratase	A,B	3-dehydroquinase,Type I DHQase,Type I dehydroquinase,DHQ1
	ec: 4.2.1.10

Source :

mol_id	organism_scientific	expression_system
1	Salmonella enterica subsp. enterica serovar Typhi (taxid:90370)	Escherichia coli (taxid:562)
	atcc: 19430 gene: aroD, STY1760, t1231 expression_system_vector_type: plasmid

Authors :

Sanz-Gaitero, M., Maneiro, M., Lence, E., Otero, J.M., Thompson, P., Hawkins, A.R., Gonzalez-Bello, C., van Raaij, M.J.

Keywords :

lyase activity, chorismate biosynthetic process, 3-dehydroquinase, covalent inhibitor, lyase

Exp. method :

X-RAY DIFFRACTION ( 1.14 Å )

Citation :

Hydroxylammonium Derivatives for Selective Active-site Lysine Modification in the Anti-virulence Bacterial Target DHQ1 Enzyme.

Maneiro, M.,Lence, E.,Sanz-Gaitero, M. et al.
(2019) Org Chem Front 9 : 3127 - 3135

Chain :

A, B

UniProt :

P24670 (AROD_SALTI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
3-dehydroquinate = 3-dehydroshikimate + H2O	4.2.1.10	HAMAP- Rule:MF_00214, PubMed:24957267
3-dehydroquinate = 3-dehydroshikimate + H2O	-	HAMAP- Rule:MF_00214, PubMed:24957267

PDB ID: 6H5C