Brand  (β version)

PDB ID: 6H59

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Ligands
Code Name Style Show Link
1PE Pentaethylene glycol PoSSuM
FQT [(2~{S})-3-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-azanyl-2-oxidanylidene-1,4-dihydropyrimidin-3-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-2-hexanoyloxy-propyl] hexanoate PoSSuM
MG Magnesium ion PoSSuM
OLB (2s)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
PGE Triethylene glycol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6H59   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase (PgsA1) with CDP-DAG bound
Release Data : 2019-05-15
Compound :
mol_id molecule chains synonym
1 CDP-diacylglycerol--inositol 3-phosphatidyltransferase A,B Phosphatidylinositol synthase,PI synthase
ec: 2.7.8.11
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)  (taxid:83332) Escherichia coli BL21(DE3)  (taxid:469008)
gene: pgsA1, Rv2612c
expression_system_variant: Rosetta 2
Authors : Grave, K., Hogbom, M.
Keywords : Phosphotransferase, Glycerophospholipid metabolism, Metal binding protein, Membrane protein, transferase
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Structure ofMycobacterium tuberculosisphosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis.

Grave, K.,Bennett, M.D.,Hogbom, M.
(2019)  Commun Biol  2 : 175 - 175

PubMed: 31098408
DOI: 10.1038/s42003-019-0427-1

Reaction

Chain : A, B
UniProt : P9WPG7 (PIPS_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) - PubMed:26510127, PubMed:31098408
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1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero- 3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) - PubMed:26510127, PubMed:31098408
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