PDB ID: 6H4O
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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ZN | Zinc ion | PoSSuM | |||
FQH | 8-[4-[2-[4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-D]pyrimidin-4-one | PoSSuM | |||
GOL | Glycerol | PoSSuM | |||
CL | Chloride ion | PoSSuM |
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Download interaction data: 6H4O
Structure summary
Code : | 6H4O PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Crystal structure of human KDM4A in complex with compound 18a | ||||||||||||
Release Data : | 2019-06-12 | ||||||||||||
Compound : |
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Authors : | Le Bihan, Y.V., van Montfort, R.L.M. | ||||||||||||
Keywords : | Histone demethylase, Inhibitor, transcription, OXIDOREDUCTASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.25 Å ) | ||||||||||||
Citation : |
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Le Bihan, Y.V.,Lanigan, R.M.,Atrash, B.
et al.
PubMed: 31158747 |
Reaction
Chain : | A, B, C, D | ||||||||||||
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UniProt : | O75164 (KDM4A_HUMAN) | ||||||||||||
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