Brand  (β version)

PDB ID: 6H38

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Ligands
Code Name Style Show Link
FKK 4-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]carbonylbenzenesulfonamide PoSSuM
GOL Glycerol PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6H38   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : The crystal structure of human carbonic anhydrase VII in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide.
Release Data : 2018-12-19
Compound :
mol_id molecule chains synonym
1 Carbonic anhydrase 7 A Carbonate dehydratase VII,Carbonic anhydrase VII,CA-VII
ec: 4.2.1.1
mutation: C183S, C217S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CA7
Authors : Buemi, M.R., Di Fiore, A., De Luca, L., Ferro, S., Mancuso, F., Monti, S.M., Buonanno, M., Angeli, A., Russo, E., De Sarro, G., Supuran, C.T., De Simone, G., Gitto, R.
Keywords : Protein-Inhibitor Binding, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.

Buemi, M.R.,Di Fiore, A.,De Luca, L.  et al.
(2018)  Eur J Med Chem  163 : 443 - 452

PubMed: 30530195
DOI: 10.1016/j.ejmech.2018.11.073

Reaction

Chain : A
UniProt : P43166 (CAH7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + hydrogencarbonate = CO2 + H2O 4.2.1.1 -
-