Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
EDO 1,2-ethanediol
FE Fe (III) ion
FJE [3-azanyl-2,6-bis(fluoranyl)phenyl]-(5-chloranyl-1~{H}-pyrrolo[2,3-B]pyridin-3-yl)methanone
GOL Glycerol
Code : 6H1H
Header : TRANSCRIPTION
Title : Crystal structure of human Pirin in complex with compound 7 (PLX4720)
Release Data : 2018-11-28
Compound :
mol_id molecule chains synonym
1 Pirin A Probable quercetin 2,3-dioxygenase PIR,Probable quercetinase
ec: 1.13.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PIR
expression_system_vector_type: Plasmid
Authors : Ali, S., Le Bihan, Y.V., van Montfort, R.L.M.
Keywords : Transcriptional coregulator, Quercetin 2, 3-dioxygenase, Inhibitor, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 1.54 Å )
Citation :

Privileged Structures and Polypharmacology within and between Protein Families.

Meyers, J.,Chessum, N.E.A.,Ali, S.  et al.
(2018)  ACS Med Chem Lett  9 : 1199 - 1204

PubMed: 30613326
DOI: 10.1021/acsmedchemlett.8b00364

Chain : A
UniProt : O00625 (PIR_HUMAN)
Reaction : Quercetin + O(2) = 2-(3,4- dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H(+).