Brand  (β version)

PDB ID: 6H1H

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
FE Fe (III) ion PoSSuM
FJE [3-azanyl-2,6-bis(fluoranyl)phenyl]-(5-chloranyl-1~{H}-pyrrolo[2,3-B]pyridin-3-yl)methanone PoSSuM
GOL Glycerol PoSSuM
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Structure summary

Code : 6H1H   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of human Pirin in complex with compound 7 (PLX4720)
Release Data : 2018-11-28
Compound :
mol_id molecule chains synonym
1 Pirin A Probable quercetin 2,3-dioxygenase PIR,Probable quercetinase
ec: 1.13.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PIR
expression_system_vector_type: Plasmid
Authors : Ali, S., Le Bihan, Y.V., van Montfort, R.L.M.
Keywords : Transcriptional coregulator, Quercetin 2, 3-dioxygenase, Inhibitor, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 1.54 Å )
Citation :

Privileged Structures and Polypharmacology within and between Protein Families.

Meyers, J.,Chessum, N.E.A.,Ali, S.  et al.
(2018)  ACS Med Chem Lett  9 : 1199 - 1204

PubMed: 30613326
DOI: 10.1021/acsmedchemlett.8b00364

Reaction

Chain : A
UniProt : O00625 (PIR_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6- dihydroxybenzoate + CO 1.13.11.24 PubMed:15951572
-
Cofactor: Evidence: Note:
Fe cation ECO:0000269 | PubMed:14573596
ECO:0000269 | PubMed:20711196
Binds 1 Fe cation per subunit.