Brand  (β version)

PDB ID: 6GZV

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Ligands
Code Name Style Show Link
FHK 4-[[4-[1,3-bis(oxidanylidene)isoindol-2-yl]phenyl]sulfonylamino]benzoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6GZV   PDBj   RCSB PDB   PDBe
Header : VIRUS
Title : Identification of a druggable VP1-VP3 interprotomer pocket in the capsid of enteroviruses
Release Data : 2019-06-05
Compound :
mol_id molecule chains
1 Capsid protein VP1 A
ec: 3.4.22.29,3.6.1.15,3.4.22.28,2.7.7.48
mol_id molecule chains
2 Capsid protein VP2 B
ec: 3.4.22.29,3.6.1.15,3.4.22.28,2.7.7.48
mol_id molecule chains
3 Capsid protein VP3 C
ec: 3.4.22.29,3.6.1.15,3.4.22.28,2.7.7.48
mol_id molecule chains
4 Capsid protein VP4 D
ec: 3.4.22.29,3.6.1.15,3.4.22.28,2.7.7.48
Source :
mol_id organism_scientific
1 Coxsackievirus B3 (strain Nancy)  (taxid:103903)
strain: Nancy
mol_id organism_scientific
2 Coxsackievirus B3 (strain Nancy)  (taxid:103903)
strain: Nancy
mol_id organism_scientific
3 Coxsackievirus B3 (strain Nancy)  (taxid:103903)
strain: Nancy
mol_id organism_scientific
4 Coxsackievirus B3 (strain Nancy)  (taxid:103903)
strain: Nancy
Authors : Geraets, J.A., Flatt, J.W., Domanska, A., Butcher, S.J.
Keywords : Inhibitor, complex, virus
Exp. method : ELECTRON MICROSCOPY ( 4.0 Å )
Citation :

A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses.

Abdelnabi, R.,Geraets, J.A.,Ma, Y.  et al.
(2019)  Plos Biol.  17 : e3000281 - e3000281

PubMed: 31185007
DOI: 10.1371/journal.pbio.3000281

Reaction

Chain : D
UniProt : P03313 (POLG_CXB3N)
Reaction: EC: Evidence:
Physiological Direction:
[Protein 2C]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 		3.6.1.15 UniProtKB:P03300
-
[Protease 2A]
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. 		3.4.22.29 UniProtKB:P03300
-
[RNA-directed RNA polymerase]
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 		2.7.7.48 PROSITE-ProRule:PRU00539
-
[Protease 3C]
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 		3.4.22.28 PROSITE-ProRule:PRU01222
-