Het-PDB Navi2 (PDB: 6GXQ)

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Color scheme of protein:

Ligands
Code	Name	Link
MG	Magnesium ion	PoSSuM
ZN	Zinc ion	PoSSuM
GAI	Guanidine	PoSSuM
FFZ	3-[5-[(4ar,8as)-4-oxidanylidene-3-propan-2-yl-4a,5,8,8a-tetrahydrophthalazin-1-yl]-2-methoxy-phenyl]-N-(phenylmethyl)prop-2-ynamide	PoSSuM
GOL	Glycerol	PoSSuM

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Download interaction data: 6GXQ

Code :

6GXQ PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1335

Release Data :

2019-07-10

Compound :

mol_id	molecule	chains
1	Phosphodiesterase	A,B
	ec: 3.1.4.- other_details: residues 565-918

Source :

mol_id	organism_scientific	expression_system
1	Trypanosoma brucei (taxid:5691)	Escherichia coli BL21(DE3) (taxid:469008)
	gene: PDEB1 expression_system_variant: codon plus expression_system_vector_type: Plasmid expression_system_plasmid: pET28a

Authors :

Singh, A.K., Brown, D.G.

Keywords :

Parasitic phosphodiesterase, hydrolase, African trypanosomiasis, sleeping sickness

Exp. method :

X-RAY DIFFRACTION ( 1.96 Å )

Citation :

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).

de Heuvel, E.,Singh, A.K.,Boronat, P. et al.
(2019) Bioorg.Med.Chem. 27 : 4013 - 4029

PDB ID: 6GXQ