Het-PDB Navi2 (PDB: 6GU7)

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Ligands
Code	Name		Style	Show	Link
FB8	4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6GU7

Code :

6GU7 PDBj RCSB PDB PDBe

Header :

CELL CYCLE

Title :

CDK1/Cks2 in complex with AZD5438

Release Data :

2018-12-05

Compound :

mol_id	molecule	chains	synonym
1	Cyclin-dependent kinase 1	A,C,E,G	CDK1,Cell division control protein 2 homolog,Cell division protein kinase 1,p34 protein kinase
	ec: 2.7.11.22,2.7.11.23

mol_id	molecule	chains	synonym
2	Cyclin-dependent kinases regulatory subunit 2	B,D,F,H	CKS-2

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: CDK1, CDC2, CDC28A, CDKN1, P34CDC2 expression_system_common: Fall armyworm expression_system_cell_line: SF9 expression_system_plasmid: pVL1393

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CKS2

Authors :

Wood, D.J., Korolchuk, S., Tatum, N.J., Wang, L.Z., Endicott, J.A., Noble, M.E.M., Martin, M.P.

Keywords :

CDK1, CKS2, INHIBITOR, CELL CYCLE

Exp. method :

X-RAY DIFFRACTION ( 2.75 Å )

Citation :

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.

Wood, D.J.,Korolchuk, S.,Tatum, N.J. et al.
(2019) Cell Chem Biol 26 : 121 - 130.e5

Chain :

A, C, E, G

UniProt :

P06493 (CDK1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.22	PubMed:23355470, PubMed:26829474, PubMed:30704899
	-	PubMed:23355470, PubMed:26829474, PubMed:30704899
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.22	PubMed:23355470, PubMed:26829474, PubMed:30704899
	-	PubMed:23355470, PubMed:26829474, PubMed:30704899
[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho- [DNA-directed RNA polymerase]	2.7.11.23	UniProtKB:P11440
	-	UniProtKB:P11440

PDB ID: 6GU7