Brand  (β version)

PDB ID: 6GT3

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Ligands
Code Name Style Show Link
CLR Cholesterol PoSSuM
F9Q 6-(2-chloranyl-6-methyl-pyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine PoSSuM
NA Sodium ion PoSSuM
OLA Oleic acid PoSSuM
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
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Structure summary

Code : 6GT3   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Crystal Structure of the A2A-StaR2-bRIL562 in complex with AZD4635 at 2.0A resolution
Release Data : 2019-06-26
Compound :
mol_id molecule chains synonym
1 Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a A Cytochrome b-562
mutation: A54L, T88A, R107A, K122A, N154A, L202A, M1007W, H1102I, L235A, V239A, S277A,A54L, T88A, R107A, K122A, N154A, L202A, M1007W, H1102I, L235A, V239A, S277A,A54L, T88A, R107A, K122A, N154A, L202A, M1007W, H1102I, L235A, V239A, S277A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: ADORA2A, ADORA2
expression_system_common: Cabbage looper
Authors : Borodovsky, A., Wang, Y., Deng, N., Ye, M., Stephen, T.L., Goodwin, K., Goodwin, R., Strittmatter, N., Shaw, J., Sachsenmeier, K., Clarke, J.D., Hay, C., Reimer, C., Andrews, S.P., Brown, G.A., Congreve, M., Cheng, R.K.Y., Dore, A.S., Mason, J.S., Marshall, F.H., Weir, M.P., Lyne, P., Woessner, R.
Keywords : 7TM, GPCR, SIGNALLING PROTEIN, MEMBRANE PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity

Borodovsky, A.,Barbon, C.M.,Wang, Y.  et al.
(2020)  J Immunother Cancer 

Reaction

Chain : A
UniProt : P29274 (AA2AR_HUMAN)
Reaction : -
Chain : A
UniProt : P0ABE7 (C562_ECOLX)
Reaction : -