PDB ID: 6GQP
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Structure summary
Code : | 6GQP PDBj RCSB PDB PDBe | ||||||||||||
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Header : | SIGNALING PROTEIN | ||||||||||||
Title : | Crystal structure of human KDR (VEGFR2) kinase domain in complex with AZD3229-analogue (compound 23) | ||||||||||||
Release Data : | 2018-09-19 | ||||||||||||
Compound : |
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Source : |
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Authors : | Hardy, C.J., Schimpl, M., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y. | ||||||||||||
Keywords : | receptor tyrosine kinase, inhibitor, oncology, gastrointestinal stromal tumour, structure-based drug design, SIGNALING PROTEIN | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.09 Å ) | ||||||||||||
Citation : |
Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
Kettle, J.G.,Anjum, R.,Barry, E.
et al.
PubMed: 30204441 |
Reaction
Chain : | A | ||||||||
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UniProt : | P35968 (VGFR2_HUMAN) | ||||||||
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