Brand  (β version)

PDB ID: 6GPX

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
OLA Oleic acid PoSSuM
F7N [(3~{S},4~{S})-3-methoxyoxan-4-yl]-[(1~{R},3~{S})-3-propan-2-yl-3-[[3-(trifluoromethyl)-7,8-dihydro-5~{H}-1,6-naphthyridin-6-yl]carbonyl]cyclopentyl]azanium PoSSuM
Non-standard Residues
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Structure summary

Code : 6GPX   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : CRYSTAL STRUCTURE OF CCR2A IN COMPLEX WITH MK-0812
Release Data : 2019-01-02
Compound :
mol_id molecule chains synonym
1 C-C chemokine receptor type 2,Rubredoxin,C-C chemokine receptor type 2 A,B CCR2,Monocyte chemoattractant protein 1 receptor,MCP-1-R,Rd,CCR2,Monocyte chemoattractant protein 1 receptor,MCP-1-R
fragment: RUBREDOXIN INSERTED INTO CCR2A BETWEEN RESIDUE 231 AND 235,RUBREDOXIN INSERTED INTO CCR2A BETWEEN RESIDUE 231 AND 235,RUBREDOXIN INSERTED INTO CCR2A BETWEEN RESIDUE 231 AND 235
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CCR2, CMKBR2
expression_system_common: Fall armyworm
Authors : Pautsch, A., Schnapp, G., Cheng, R., Apel, A.
Keywords : GPCR, Signalling, Drug-design, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.

Apel, A.K.,Cheng, R.K.Y.,Tautermann, C.S.  et al.
(2019)  Structure  27 : 427 - 438.e5

PubMed: 30581043
DOI: 10.1016/j.str.2018.10.027

Reaction

Chain : A, B
UniProt : P41597 (CCR2_HUMAN)
Reaction : -
Chain : A, B
UniProt : P00268 (RUBR_CLOPA)
Reaction : -