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Ligands
Code Name Style Show Link
BCN Bicine
EDO 1,2-ethanediol
F7E [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},6~{R})-6-methyl-3,4-bis(oxidanyl)-5-oxidanylidene-oxan-2-yl] hydrogen phosphate
NAP Nadp nicotinamide-adenine-dinucleotide phosphate
Non-standard Residues
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Glycosylation
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Code : 6GPL   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of human GDP-D-mannose 4,6-dehydratase in complex with GDP-4k6d-Man
Release Data : 2018-07-18
Compound :
mol_id molecule chains synonym
1 GDP-mannose 4,6 dehydratase B,C,D,E GDP-D-mannose dehydratase,GMD
ec: 4.2.1.47
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: GMDS
Authors : Pfeiffer, M., Krojer, T., Johansson, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Nidetzky, B., Oppermann, U., Structural Genomics Consortium (SGC)
Keywords : Structural Genomics, Structural Genomics Consortium, SGC, Lyase
Exp. method : X-RAY DIFFRACTION ( 1.76 Å )
Citation :

A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase.

Pfeiffer, M.,Johansson, C.,Krojer, T.  et al.
(2019)  Acs Catalysis  9 : 2962 - 2968

PubMed: 30984471
DOI: 10.1021/acscatal.9b00064

Chain : B, C, D, E
UniProt : O60547 (GMDS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O 4.2.1.47 PubMed:9525924
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