Brand  (β version)

PDB ID: 6GOU

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
F6T (3~{S})-3-[2,6-bis(fluoranyl)phenyl]-~{N}-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)methyl]butanamide PoSSuM
Non-standard Residues
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Structure summary

Code : 6GOU   PDBj   RCSB PDB   PDBe
Header : FLAVOPROTEIN
Title : Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I
Release Data : 2019-01-02
Compound :
mol_id molecule chains synonym
1 Alkyldihydroxyacetonephosphate synthase, peroxisomal D,A,B,C Alkyl-DHAP synthase,Alkylglycerone-phosphate synthase
ec: 2.5.1.26
Source :
mol_id organism_scientific organism_common expression_system
1 Cavia porcellus  (taxid:10141) Guinea pig Escherichia coli  (taxid:562)
gene: AGPS
Authors : Mattevi, A., Piano, V.
Keywords : Ether phospholipids, catalytic mechanism, inhibitor, anti-cancer, FLAVOPROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells.

Stazi, G.,Battistelli, C.,Piano, V.  et al.
(2018)  Eur J Med Chem  163 : 722 - 735

PubMed: 30576903
DOI: 10.1016/j.ejmech.2018.11.050

Reaction

Chain : D, A, B, C
UniProt : P97275 (ADAS_CAVPO)
Reaction: EC: Evidence:
Physiological Direction:
a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+) 2.5.1.26 PubMed:10692424, PubMed:23112191, PubMed:8399344, PubMed:9989261
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1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O- hexadecylglycerone 3-phosphate + H(+) + hexadecanoate - PubMed:10692424, PubMed:8399344, PubMed:9989261
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1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate - UniProtKB:Q8C0I1
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