Het-PDB Navi2 (PDB: 6GNJ)

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Ligands
Code	Name		Style	Show	Link
F4W	3-(12-oxidanylidene-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9-trien-10-yl)propanoic acid				PoSSuM

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Download interaction data: 6GNJ

Code :

6GNJ PDBj RCSB PDB PDBe

Header :

TOXIN

Title :

Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form in complex with STO1101

Release Data :

2018-09-26

Compound :

mol_id	molecule	chains	synonym
1	14-3-3 protein beta/alpha	A,B	Protein 1054,Protein kinase C inhibitor protein 1,KCIP-1

mol_id	molecule	chains
2	Exoenzyme S	C
	mutation: E379A, E381A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: YWHAB expression_system_vector_type: PLASMID expression_system_plasmid: pET Duet-1

mol_id	organism_scientific	expression_system
2	Pseudomonas aeruginosa (taxid:287)	Escherichia coli (taxid:562)
	gene: exoS expression_system_vector_type: PLASMID expression_system_plasmid: pET Duet-1

Authors :

Karlberg, T., Pinto, A.F., Hornyak, P., Thorsell, A.G., Nareoja, K., Schuler, H.

Keywords :

EXOS, PSEUDOMONAS AERUGINOSA, ADP-RIBOSYLATION, NAD, TOXIN

Exp. method :

X-RAY DIFFRACTION ( 3.24 Å )

Citation :

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.

Karlberg, T.,Hornyak, P.,Pinto, A.F. et al.
(2018) Nat Commun 9 : 3785 - 3785

PDB ID: 6GNJ