Brand  (β version)

PDB ID: 6GMX

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Ligands
Code Name Style Show Link
F7B 6-chloranyl-2,3-dihydrothiochromen-4-one PoSSuM
IPA Isopropyl alcohol PoSSuM
Non-standard Residues
Code Name Show
CAS S-(dimethylarsenic)cysteine
Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 6GMX   PDBj   RCSB PDB   PDBe
Header : ONCOPROTEIN
Title : pVHL:EloB:EloC in complex with 6-chlorothiochroman-4-one
Release Data : 2018-08-08
Compound :
mol_id molecule chains synonym
1 Elongin-B A,G,J EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
other_details: S-(DIMETHYLARSENIC)CYSTEINE modification
mol_id molecule chains synonym
2 Elongin-C B,H,K EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
other_details: 2nd N at N-treminus resulting from cloning
mol_id molecule chains synonym
3 von Hippel-Lindau disease tumor suppressor C,F,I,L Protein G7,pVHL
other_details: residues 54-213 GS at N-terminus from cloning S-(DIMETHYLARSENIC)CYSTEINE modification
mol_id molecule chains synonym
4 Elongin-B D EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
other_details: S-(DIMETHYLARSENIC)CYSTEINE modification
mol_id molecule chains synonym
5 Elongin-C E EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
other_details: 2nd N at N-treminus resulting from cloning
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ELOB, TCEB2
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ELOC, TCEB1
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: VHL
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ELOB, TCEB2
mol_id organism_scientific organism_common expression_system
5 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ELOC, TCEB1
Authors : Van Molle, I., Lucas, X., Ciulli, A.
Keywords : E3 ubiquitin ligase, tumor supressor, PROTAC, fragment-based drug discovery, ONCOPROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.533 Å )
Citation :

Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.

Lucas, X.,Van Molle, I.,Ciulli, A.
(2018)  J. Med. Chem.  61 : 7387 - 7393

PubMed: 30040896
DOI: 10.1021/acs.jmedchem.8b00842

Reaction

Chain : D
UniProt : Q15370 (ELOB_HUMAN)
Reaction : -
Chain : E
UniProt : Q15369 (ELOC_HUMAN)
Reaction : -
Chain : C, F, I, L
UniProt : P40337 (VHL_HUMAN)
Reaction : -