Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide
FGT 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one
UMP 2'-deoxyuridine 5'-monophosphate
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 6GKO   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Mouse thymidylate synthase cocrystallized with dUMP and soaked in phenolphthalein
Release Data : 2019-06-05
Compound :
mol_id molecule chains synonym
1 Thymidylate synthase A,B TSase
ec: 2.1.1.45
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:562)
gene: Tyms
Authors : Maj, P., Wilk, P., Jarmula, A., Weiss, M.S., Rode, W.
Keywords : fragment screening, fragment, inhibitor, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.839 Å )
Citation :

Thymidylate synthase fragment screening

Maj, P.,Wilk, P.,Jarmula, A.  et al.
To Be Published 

Chain : A, B
UniProt : P07607 (TYSY_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP 2.1.1.45 UniProtKB:P45352
left-to-right