Brand  (β version)

PDB ID: 6GK9

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Ligands
Code Name Style Show Link
F2K (5~{S})-7-azanyl-5-(4-chlorophenyl)-2,4-bis(oxidanylidene)-1,5-dihydropyrano[2,3-D]pyrimidine-6-carbonitrile PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6GK9   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Inhibited structure of IMPDH from Pseudomonas aeruginosa
Release Data : 2019-02-27
Compound :
mol_id molecule chains synonym
1 Inosine-5'-monophosphate dehydrogenase A,B,C,D,E,F,G,H IMPDH
ec: 1.1.1.205
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa PAO1  (taxid:208964) Escherichia coli  (taxid:562)
gene: guaB, PA3770
Authors : Labesse, G., Alexandre, T., Haouz, A., Munier-Lehmann, H.
Keywords : IMP dehydrogenase, nucleotide biosynthesis, allosteric regulation, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.5400 Å )
Citation :

First-in-class allosteric inhibitors of bacterial IMPDHs.

Alexandre, T.,Lupan, A.,Helynck, O.  et al.
(2019)  Eur J Med Chem  167 : 124 - 132

PubMed: 30769241
DOI: 10.1016/j.ejmech.2019.01.064

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : Q9HXM5 (Q9HXM5_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
H2O + IMP + NAD(+) = H(+) + NADH + XMP 1.1.1.205 ARBA:ARBA00024264, HAMAP-Rule:MF_01964, RuleBase:RU003928
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