Brand  (β version)

PDB ID: 6GJO

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Ligands
Code Name Style Show Link
F1B (3~{z})-5-ethanoyl-3-[[(1-methylpiperidin-4-yl)amino]-phenyl-methylidene]-1~{H}-indol-2-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6GJO   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Glycogen Synthase Kinase-3 beta in Complex with BI-91BS
Release Data : 2019-03-27
Compound :
mol_id molecule chains synonym
1 Glycogen synthase kinase-3 beta A,B GSK-3 beta,Serine/threonine-protein kinase GSK3B
ec: 2.7.11.26,2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GSK3B
expression_system_common: Fall armyworm
Authors : Hoerer, S.
Keywords : KINASE, INDOLINONE, GSK3, ATP-BINDING, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, WNT SIGNALING PATHWAY, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.91 Å )
Citation :

CRYSTAL STRUCTURE OF Glycogen synthase kinase-3 beta IN COMPLEX WITH BI-91BS

Hoerer, S.
To Be Published 

Reaction

Chain : A, B
UniProt : P49841 (GSK3B_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein] 2.7.11.26 PubMed:14690523
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ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein] 2.7.11.26 PubMed:14690523
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ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:17050006, PubMed:22539723, PubMed:28992046
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:17050006
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