Het-PDB Navi2 (PDB: 6GJB)

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Ligands
Code	Name		Style	Show	Link
F0H	[(1~{R},4~{z})-cyclooct-4-en-1-yl] ~{N}-[4-[4-[[4-[1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-2-oxidanylidene-pyridin-4-yl]pyrimidin-2-yl]amino]pyridin-2-yl]but-3-ynyl]carbamate				PoSSuM
SO4	Sulfate ion				PoSSuM

Non-standard Residues
Code	Name	Show
CME	S,S-(2-hydroxyethyl)thiocysteine

Glycosylation
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Download interaction data: 6GJB

Code :

6GJB PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN

Title :

Erk2 signalling protein

Release Data :

2019-01-02

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 1	A	MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2
	ec: 2.7.11.24

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: MAPK1, ERK2, PRKM1, PRKM2

Authors :

O'Reilly, M.

Keywords :

Erk2, inhibitor, reversible probe, SIGNALING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 1.82 Å )

Citation :

Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe.

Lebraud, H.,Surova, O.,Courtin, A. et al.
(2018) Chem Sci 9 : 8608 - 8618

PDB ID: 6GJB