Brand  (β version)

PDB ID: 6GIQ

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Ligands
Code Name Style Show Link
6PH (1r)-2-(phosphonooxy)-1-[(tridecanoyloxy)methyl]ethyl pentadecanoate PoSSuM
7PH (1r)-2-(dodecanoyloxy)-1-[(phosphonooxy)methyl]ethyl tetradecanoate PoSSuM
8PE (2r)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate PoSSuM
9PE (1r)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate PoSSuM
CN3 (2r,5s,11r,14r)-5,8,11-trihydroxy-2-(nonanoyloxy)-5,11-dioxido-16-oxo-14-[(propanoyloxy)methyl]-4,6,10,12,15-pentaoxa-5,11-diphosphanonadec-1-yl undecanoate PoSSuM
CN5 (5s,11r)-5,8,11-trihydroxy-5,11-dioxido-17-oxo-4,6,10,12,16-pentaoxa-5,11-diphosphaoctadec-1-yl pentadecanoate PoSSuM
CU Copper (II) ion PoSSuM
CUA Dinuclear copper ion PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
HEA Heme-a PoSSuM
HEC Heme C PoSSuM
PCF 1,2-diacyl-sn-glycero-3-phoshocholine PoSSuM
UQ6 5-(3,7,11,15,19,23-hexamethyl-tetracosa-2,6,10,14,18,22-hexaenyl)-2,3-dimethoxy-6-methyl-benzene-1,4-diol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6GIQ   PDBj   RCSB PDB   PDBe
Header : ELECTRON TRANSPORT
Title : Saccharomyces cerevisiae respiratory supercomplex III2IV
Release Data : 2019-01-02
Compound :
mol_id molecule chains synonym
1 BJ4_G0001550.mRNA.1.CDS.1 A,L COR1 isoform 1,Cytochrome b-c1 complex subunit 1,mitochondrial,Y55_G0001550.mRNA.1.CDS.1
mol_id molecule chains synonym
2 Cytochrome b-c1 complex subunit 2, mitochondrial B,M QCR2 isoform 1
mol_id molecule chains
3 Cytochrome b C,N
mol_id molecule chains synonym
4 BJ4_G0049990.mRNA.1.CDS.1 D,O CYT1 isoform 1,Cytochrome c1,heme protein,mitochondrial,HLJ1_G0050000.mRNA.1.CDS.1,JXXY16.1_G0049800.mRNA.1.CDS.1,SX2_G0049550.mRNA.1.CDS.1,Y55_G0049920.mRNA.1.CDS.1
mol_id molecule chains
5 Cytochrome b-c1 complex subunit Rieske, mitochondrial E,P
ec: 7.1.1.8
mol_id molecule chains synonym
6 QCR6 isoform 1 F,Q Y55_G0017620.mRNA.1.CDS.1
mol_id molecule chains
7 Complex III subunit 7 G,R
mol_id molecule chains synonym
8 BJ4_G0028260.mRNA.1.CDS.1 H,S EM14S01-3B_G0028260.mRNA.1.CDS.1,HLJ1_G0028200.mRNA.1.CDS.1,HN1_G0028080.mRNA.1.CDS.1,JXXY16.1_G0025710.mRNA.1.CDS.1,QCR8 isoform 1,SX2_G0028380.mRNA.1.CDS.1,XXYS1_G0028300.mRNA.1.CDS.1,Y55_G0028450.mRNA.1.CDS.1
mol_id molecule chains synonym
9 HLJ1_G0021680.mRNA.1.CDS.1 I,T HN1_G0021630.mRNA.1.CDS.1,SX2_G0021700.mRNA.1.CDS.1,Y55_G0021900.mRNA.1.CDS.1
mol_id molecule chains synonym
10 BJ4_G0023510.mRNA.1.CDS.1 U,V EM14S01-3B_G0023320.mRNA.1.CDS.1,HLJ1_G0023290.mRNA.1.CDS.1,HN1_G0023260.mRNA.1.CDS.1,JXXY16.1_G0041640.mRNA.1.CDS.1,XXYS1_G0023360.mRNA.1.CDS.1,Y55_G0023430.mRNA.1.CDS.1
mol_id molecule chains synonym
11 Cytochrome c oxidase subunit 1 a Cytochrome c oxidase polypeptide I
ec: 7.1.1.9
mol_id molecule chains
12 Cytochrome c oxidase subunit 2 b
mol_id molecule chains
13 Cytochrome c oxidase subunit 3 c
mol_id molecule chains synonym
14 BJ4_G0018620.mRNA.1.CDS.1 d COX4 isoform 1,Cytochrome c oxidase subunit 4,mitochondrial,EM14S01-3B_G0018320.mRNA.1.CDS.1,HLJ1_G0018360.mRNA.1.CDS.1,HN1_G0018250.mRNA.1.CDS.1,JXXY16.1_G0018520.mRNA.1.CDS.1,SX2_G0018350.mRNA.1.CDS.1,XXYS1_G0018320.mRNA.1.CDS.1,Y55_G0018590.mRNA.1.CDS.1
mol_id molecule chains synonym
15 BJ4_G0046460.mRNA.1.CDS.1 e COX5A isoform 1,Cytochrome c oxidase subunit 5A,mitochondrial,HLJ1_G0046380.mRNA.1.CDS.1,HN1_G0046310.mRNA.1.CDS.1,SX2_G0046080.mRNA.1.CDS.1,Y55_G0046480.mRNA.1.CDS.1
mol_id molecule chains synonym
16 BJ4_G0024040.mRNA.1.CDS.1 f COX6 isoform 1,Cytochrome c oxidase subunit 6,mitochondrial,HLJ1_G0023830.mRNA.1.CDS.1,SX2_G0023870.mRNA.1.CDS.1,Y55_G0023980.mRNA.1.CDS.1
mol_id molecule chains synonym
17 BJ4_G0043230.mRNA.1.CDS.1 g COX7 isoform 1,EM14S01-3B_G0043140.mRNA.1.CDS.1,HLJ1_G0043160.mRNA.1.CDS.1,HN1_G0042940.mRNA.1.CDS.1,JXXY16.1_G0040380.mRNA.1.CDS.1,SX2_G0042750.mRNA.1.CDS.1,XXYS1_G0042950.mRNA.1.CDS.1,Y55_G0043120.mRNA.1.CDS.1
mol_id molecule chains synonym
18 BJ4_G0038800.mRNA.1.CDS.1 h COX8 isoform 1,HLJ1_G0038810.mRNA.1.CDS.1,HN1_G0038550.mRNA.1.CDS.1,SX2_G0038370.mRNA.1.CDS.1
mol_id molecule chains synonym
19 Cytochrome c oxidase polypeptide VIIA i Cytochrome c oxidase subunit 9,mitochondrial
mol_id molecule chains synonym
20 BJ4_G0035470.mRNA.1.CDS.1 j COX12 isoform 1,EM14S01-3B_G0035180.mRNA.1.CDS.1,HLJ1_G0035620.mRNA.1.CDS.1,HN1_G0035360.mRNA.1.CDS.1,JXXY16.1_G0032480.mRNA.1.CDS.1,SX2_G0035180.mRNA.1.CDS.1,XXYS1_G0035020.mRNA.1.CDS.1,Y55_G0035530.mRNA.1.CDS.1
mol_id molecule chains synonym
21 Cytochrome c oxidase subunit k Cytochrome c oxidase polypeptide VIa
mol_id molecule chains
22 Unknown Cox subunit m
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
2 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
3 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
4 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
5 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
6 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
7 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
8 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
9 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
10 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
11 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
12 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
13 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
14 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
15 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
16 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
17 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
18 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
19 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
20 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
21 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
22 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
Authors : Rathore, S., Berndtsson, J., Conrad, J., Ott, M.
Keywords : Respiratory chain, supercomplex, bc1 complex, cytochrome c oxidase, ELECTRON TRANSPORT
Exp. method : ELECTRON MICROSCOPY ( 3.23 Å )
Citation :

Cryo-EM structure of the yeast respiratory supercomplex.

Rathore, S.,Berndtsson, J.,Marin-Buera, L.  et al.
(2019)  Nat. Struct. Mol. Biol.  26 : 50 - 57

PubMed: 30598556
DOI: 10.1038/s41594-018-0169-7

Reaction

Chain : A, L
UniProt : A0A6A5Q3X1
Reaction : -
Chain : B, M
UniProt : A0A6A5Q625
Reaction : -
Chain : C, N
UniProt : A0A0G3F5W7 (A0A0G3F5W7_YEASX)
Reaction : -
Cofactor: Evidence: Note:
heme b ECO:0000256 | RuleBase:RU362117
Binds 2 heme groups non-covalently.
heme ECO:0000256 | PIRSR:PIRSR038885-2
Binds 2 heme groups non-covalently.
Chain : D, O
UniProt : A0A5B9RH60 (A0A5B9RH60_YEASX)
Reaction: EC: Evidence:
Physiological Direction:
a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out) 7.1.1.8 ARBA:ARBA00029351
-
Cofactor: Evidence: Note:
heme c ECO:0000256 | PIRSR:PIRSR602326-1
Binds 1 heme c group covalently per subunit.
Chain : E, P
UniProt : A0A6A5PX11
Reaction : -
Chain : F, Q
UniProt : A0A6A5Q022
Reaction : -
Chain : G, R
UniProt : A0A6A5Q2H4
Reaction : -
Chain : H, S
UniProt : A0A6A5PU80
Reaction : -
Chain : I, T
UniProt : A0A6L0Z0I8
Reaction : -
Chain : U, V
UniProt : A0A6L0ZE60
Reaction : -
Chain : a
UniProt : P00401 (COX1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)- [cytochrome c] + 2 H2O + 4 H(+)(out) 7.1.1.9 PubMed:30598554
left-to-right
Cofactor: Evidence: Note:
heme ECO:0000269 | PubMed:30598554
ECO:0000269 | PubMed:30598556
Binds 2 heme A groups non-covalently per subunit.
Cu cation - Binds a copper B center.
Chain : b
UniProt : A0A0H3WI21 (A0A0H3WI21_YEASX)
Reaction: EC: Evidence:
Physiological Direction:
4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)- [cytochrome c] + 2 H2O + 4 H(+)(out) 7.1.1.9 ARBA:ARBA00049512
left-to-right
Cofactor: Evidence: Note:
Cu cation ECO:0000256 | RuleBase:RU000457
Binds a copper A center.
Chain : c
UniProt : A0A0G3F1J2 (A0A0G3F1J2_YEASX)
Reaction: EC: Evidence:
Physiological Direction:
4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)- [cytochrome c] + 2 H2O + 4 H(+)(out) 7.1.1.9 ARBA:ARBA00049512
left-to-right
Chain : d
UniProt : A0A6A5PV33
Reaction : -
Chain : e
UniProt : A0A6A5Q8F6
Reaction : -
Chain : f
UniProt : A0A6A5PUE0
Reaction : -
Chain : g
UniProt : A0A6A5PQU1
Reaction : -
Chain : h
UniProt : A0A6A5PRD8
Reaction : -
Chain : i
UniProt : A0A6A5Q104
Reaction : -
Chain : j
UniProt : A0A6A5PU81
Reaction : -
Chain : k
UniProt : A0A6A5PWA0
Reaction : -