Brand  (β version)

PDB ID: 6G3V

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
FO9 Famotidine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6G3V   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of human carbonic anhydrase I in complex with the inhibitor famotidine
Release Data : 2018-11-28
Compound :
mol_id molecule chains synonym
1 Carbonic anhydrase 1 A,B Carbonate dehydratase I,Carbonic anhydrase B,CAB,Carbonic anhydrase I,CA-I
ec: 4.2.1.1
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
other_details: erytrocytes
Authors : Ferraroni, M., Supuran, C.T., Angeli, A.
Keywords : LYASE
Exp. method : X-RAY DIFFRACTION ( 1.6900 Å )
Citation :

Famotidine, an Antiulcer Agent, Strongly InhibitsHelicobacter pyloriand Human Carbonic Anhydrases.

Angeli, A.,Ferraroni, M.,Supuran, C.T.
(2018)  ACS Med Chem Lett  9 : 1035 - 1038

PubMed: 30344913
DOI: 10.1021/acsmedchemlett.8b00334

Reaction

Chain : A, B
UniProt : P00915 (CAH1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
hydrogencarbonate + H(+) = CO2 + H2O 4.2.1.1 PubMed:10550681, PubMed:16506782, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:17314045, PubMed:17407288, PubMed:18618712, PubMed:19186056, PubMed:19206230
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urea = cyanamide + H2O 4.2.1.69 PubMed:10550681
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Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:12009884
ECO:0000269 | PubMed:15299369
ECO:0000269 | PubMed:16506782
ECO:0000269 | PubMed:16870440
ECO:0000269 | PubMed:17314045
ECO:0000269 | PubMed:17407288
ECO:0000269 | PubMed:6430186
ECO:0000269 | PubMed:7932756
ECO:0000269 | PubMed:804171
ECO:0000269 | PubMed:8057362
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