Brand  (β version)

PDB ID: 6G37

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Ligands
Code Name Style Show Link
FTU 5-fluorotubercidin PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 6G37   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of haspin in complex with 5-fluorotubercidin
Release Data : 2018-04-18
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase haspin A Germ cell-specific gene 2 protein,H-haspin,Haploid germ cell-specific nuclear protein kinase
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: HASPIN, GSG2
expression_system_variant: R3
expression_system_vector_type: plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Heroven, C., Chaikuad, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Knapp, S., Structural Genomics Consortium (SGC)
Keywords : kinase, inhibitors, slow off-rate, kinetics, halogen, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.48 Å )
Citation :

Halogen-Aromatic pi Interactions Modulate Inhibitor Residence Times.

Heroven, C.,Georgi, V.,Ganotra, G.K.  et al.
(2018)  Angew. Chem. Int. Ed. Engl.  57 : 7220 - 7224

PubMed: 29601130
DOI: 10.1002/anie.201801666

Reaction

Chain : A
UniProt : Q8TF76 (HASP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:19918049, PubMed:19918057
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:19918049, PubMed:19918057
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