Brand  (β version)

PDB ID: 6FW9

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
FT6 6-fluoro-L-tryptophan PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6FW9   PDBj   RCSB PDB   PDBe
Header : BIOSYNTHETIC PROTEIN
Title : Crystal structure of L-tryptophan oxidase VioA from Chromobacterium violaceum in complex with 6-Fluoro-L-Tryptophan
Release Data : 2019-02-13
Compound :
mol_id molecule chains
1 Flavin-dependent L-tryptophan oxidase VioA B,A
ec: 1.4.3.23
Source :
mol_id organism_scientific expression_system
1 Chromobacterium violaceum ATCC 12472  (taxid:243365) Escherichia coli BL21(DE3)  (taxid:469008)
gene: vioA, CV_3274
expression_system_variant: pLysS
Authors : Lai, H.E., Morgan, M., Moore, S., Freemont, P.
Keywords : Violacein biosynthesis, L-tryptophan oxidase, BIOSYNTHETIC PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.739 Å )
Citation :

A GenoChemetic strategy for derivatization of the violacein natural product scaffold

Lai, H.E.,Obled, A.M.C.,Chee, S.M.  et al.
(2019)  Biorxiv 

DOI: 10.1101/202523

Reaction

Chain : B, A
UniProt : Q9S3V1 (VIOA_CHRVO)
Reaction: EC: Evidence:
Physiological Direction:
L-tryptophan + O2 = 2-iminio-3-(indol-3-yl)propanoate + H2O2 1.4.3.23 PubMed:27466367
-
7-chloro-L-tryptophan + O2 = 3-(7-chloroindol-3-yl)-2- iminopropanoate + H2O2 1.4.3.23 PubMed:27466367
-
Cofactor: Evidence: Note:
FAD ECO:0000269 | PubMed:27466367
Binds 1 FAD per subunit.
Mg(2+) ECO:0000269 | PubMed:27466367
Binds 1 Mg(2+) ion per subunit.