Het-PDB Navi2 (PDB: 6F8R)

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Ligands
Code	Name	Link
CZK	(2~{S})-1-[3-(3-cyclopentyloxy-4-methoxy-phenyl)pyrazol-1-yl]-3-morpholin-4-yl-propan-2-ol	PoSSuM
EDO	1,2-ethanediol	PoSSuM
MG	Magnesium ion	PoSSuM
ZN	Zinc ion	PoSSuM

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Download interaction data: 6F8R

Code :

6F8R PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of the PDE4D catalytic domain in complex with GEBR-54

Release Data :

2018-05-16

Compound :

mol_id	molecule	chains	synonym
1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	A,B	DPDE3,PDE43
	ec: 3.1.4.53

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: PDE4D, DPDE3

Authors :

Prosdocimi, T., Donini, S., Parisini, E.

Keywords :

PDE4, catalytic domain, inhibitor, GEBR, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.826 Å )

Citation :

Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.

Prosdocimi, T.,Mollica, L.,Donini, S. et al.
(2018) Biochemistry 57 : 2876 - 2888

Chain :

A, B

UniProt :

Q08499 (PDE4D_HUMAN)

PDB ID: 6F8R