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Ligands
Code Name Style Show Link
CZ5 6-(ethylcarbamoylamino)-4-pyrazol-1-yl-~{N}-pyridin-3-yl-pyridine-3-carboxamide
Non-standard Residues
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Glycosylation
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Code : 6F8J   PDBj   RCSB PDB   PDBe
Header : ISOMERASE
Title : Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-(1H-pyrazol-1-yl)-N-(pyridin-3-yl)pyridine-3-carboxamide
Release Data : 2019-06-26
Compound :
mol_id molecule chains
1 DNA gyrase subunit B A
ec: 5.99.1.3
Source :
mol_id organism_scientific expression_system
1 Escherichia coli O157:H7  (taxid:83334) Escherichia coli  (taxid:562)
gene: gyrB, Z5190, ECs4634
Authors : Narramore, S.K., Stevenson, C.E.M., Lawson, D.M., Maxwell, A., Fishwick, C.W.G.
Keywords : Binding Sites, DNA Gyrase, inhibitors, pyridine-3-carboxamides, topoisomerase IV, ISOMERASE
Exp. method : X-RAY DIFFRACTION ( 1.9500 Å )
Citation :

New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.

Narramore, S.,Stevenson, C.E.M.,Maxwell, A.  et al.
(2019)  Bioorg.Med.Chem.  27 : 3546 - 3550

PubMed: 31257079
DOI: 10.1016/j.bmc.2019.06.015

Chain : A
UniProt : P0AES7 (GYRB_ECO57)
Reaction: EC: Evidence:
Physiological Direction:
ATP-dependent breakage, passage and rejoining of double- stranded DNA. 5.6.2.2 HAMAP- Rule:MF_01898
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