Brand  (β version)

PDB ID: 6F8B

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CXH ~{N}-(3,4-dichlorophenyl)-2-sulfanyl-ethanamide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6F8B   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : LasB bound to thiol based inhibitor
Release Data : 2018-03-28
Compound :
mol_id molecule chains
1 Elastase A
ec: 3.4.24.26
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa  (taxid:287) Pseudomonas aeruginosa  (taxid:287)
Authors : Koehnke, J., Sikandar, A.
Keywords : LasB, inhibitor, hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.300 Å )
Citation :

Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa.

Kany, A.M.,Sikandar, A.,Haupenthal, J.  et al.
(2018)  ACS Infect Dis  4 : 988 - 997

PubMed: 29485268
DOI: 10.1021/acsinfecdis.8b00010

Reaction

Chain : A
UniProt : I6R951 (I6R951_PSEAI)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects. 3.4.24.26 ARBA:ARBA00051469
-
Cofactor: Evidence: Note:
Ca(2+) ECO:0000256 | ARBA:ARBA00001913
-
Zn(2+) ECO:0000256 | ARBA:ARBA00001947
ECO:0000256 | RuleBase:RU366073
-