Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CWW 4-(4-bromanylpyrazol-1-yl)-6-(ethylcarbamoylamino)-~{N}-pyridin-3-yl-pyridine-3-carboxamide
Code : 6F86
Header : ISOMERASE
Title : Crystal Structure of E. coli GyraseB 24kDa in complex with 4-(4-bromo-1H-pyrazol-1-yl)-6-[(ethylcarbamoyl)amino]-N-(pyridin-3-yl)pyridine-3-carboxamide
Release Data : 2019-06-26
Compound :
mol_id molecule chains
1 DNA gyrase subunit B A
ec: 5.99.1.3
Source :
mol_id organism_scientific expression_system
1 Escherichia coli O157:H7  (taxid:83334) Escherichia coli  (taxid:562)
gene: gyrB, Z5190, ECs4634
Authors : Narramore, S.K., Stevenson, C.E.M., Lawson, D.M., Maxwell, A., Fishwick, C.W.G.
Keywords : Binding Sites, DNA Gyrase, inhibitors, pyridine-3-carboxamides, topoisomerase IV, ISOMERASE
Exp. method : X-RAY DIFFRACTION ( 1.9000 Å )
Citation :

New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.

Narramore, S.,Stevenson, C.E.M.,Maxwell, A.  et al.
(2019)  Bioorg.Med.Chem.  27 : 3546 - 3550

PubMed: 31257079
DOI: 10.1016/j.bmc.2019.06.015

Chain : A
UniProt : P0AES7 (GYRB_ECO57)
Reaction : ATP-dependent breakage, passage and rejoining of double-stranded DNA.