Brand  (β version)

PDB ID: 6F5U

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Ligands
Code Name Style Show Link
CQN Bepridil PoSSuM
DMS Dimethyl sulfoxide PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 6F5U   PDBj   RCSB PDB   PDBe
Header : VIRAL PROTEIN
Title : CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH BEPRIDIL
Release Data : 2018-01-03
Compound :
mol_id molecule chains synonym
1 Envelope glycoprotein,Envelope glycoprotein,GP1 A GP1,2,GP
mol_id molecule chains synonym
2 Envelope glycoprotein B GP1,2,GP
Source :
mol_id organism_scientific organism_common expression_system
1 Ebola virus  (taxid:1570291) ZEBOV Homo sapiens  (taxid:9606)
strain: MAYINGA, ZAIRE, 1976
gene: GP
expression_system_cell_line: HEK293T
mol_id organism_scientific organism_common expression_system
2 Zaire ebolavirus (strain Mayinga-76)  (taxid:128952) ZEBOV Homo sapiens  (taxid:9606)
strain: Mayinga-76
gene: GP
expression_system_cell_line: HEK293T
Authors : Ren, J., Zhao, Y., Fry, E.E., Stuart, D.I.
Keywords : EBOLA VIRUS, FILOVIRIDAE, ENVELOPE GLYCOPROTEIN, PROTEIN INHIBITOR COMPLEX, IBUPROFEN, benztropine, bepridil, paroxetine and sertraline, TOREMIFENE, VIRAL PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.070 Å )
Citation :

Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection.

Ren, J.,Zhao, Y.,Fry, E.E.  et al.
(2018)  J. Med. Chem.  61 : 724 - 733

PubMed: 29272110
DOI: 10.1021/acs.jmedchem.7b01249

Reaction

Chain : B
UniProt : Q05320 (VGP_EBOZM)
Reaction : -