PDB ID: 6F2U
Hetero Atom Contents
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CJ2 | 3-[(4-methoxyphenyl)methyl]-5-oxidanyl-~{N}-[3-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxamide | PoSSuM | |||
NAP | Nadp nicotinamide-adenine-dinucleotide phosphate | PoSSuM |
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Download interaction data: 6F2U
Structure summary
Code : | 6F2U PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Potent and selective Aldo-Keto Reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a Bioisosteric Scaffold Hopping Approach to Flufenamic acid | ||||||||||||
Release Data : | 2018-04-04 | ||||||||||||
Compound : |
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Authors : | Goyal, P., Wahlgren, W.Y., Friemann, R. | ||||||||||||
Keywords : | aldo-keto reductase 1C3; AKR1C3; 17B-HSD5; Prostate cancer (PCa); CRPC; bioisosterism; scaffold hopping; inhibitors; X-ray crystallography, oxidoreductase | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.880 Å ) | ||||||||||||
Citation : |
Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.
Pippione, A.C.,Carnovale, I.M.,Bonanni, D.
et al.
PubMed: 29602039 |
Reaction
Chain : | A, B | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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UniProt : | P42330 (AK1C3_HUMAN) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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