Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CG5 (9~{R},10~{R},11~{S})-~{N}-[4-[3-(4-fluorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]pyridin-2-yl]-4-(4-methoxyphenyl)-10,11-bis(oxidanyl)-1,7-diazatricyclo[7.3.0.0^{3,7}]dodeca-3,5-diene-6-carboxamide
SO4 Sulfate ion
Modified Residues
Code Name Link
TPO Phosphothreonine
Code : 6F1W
Header : TRANSFERASE
Title : Crystal structure of human Casein Kinase I delta in complex with compound 31a
Release Data : 2019-03-13
Compound :
mol_id molecule chains synonym
1 Casein kinase I isoform delta A CKId,Tau-protein kinase CSNK1D
ec: 2.7.11.1,2.7.11.26
mol_id molecule chains synonym
2 Casein kinase I isoform delta B CKId,Tau-protein kinase CSNK1D
ec: 2.7.11.1,2.7.11.26
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CSNK1D, HCKID
expression_system_strain: TAKARA 2
expression_system_vector_type: pET28a
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CSNK1D, HCKID
expression_system_strain: TAKARA 2
expression_system_vector_type: pET28a
Authors : Pichlo, C., Brunstein, E., Baumann, U.
Keywords : Kinase, Inhibitor, Complex, CK1, transferase
Exp. method : X-RAY DIFFRACTION ( 1.864 Å )
Citation :

Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds.

Luxenburger, A.,Schmidt, D.,Ianes, C.  et al.
(2019)  Molecules  24

PubMed: 30832206
DOI: 10.3390/molecules24050873

Chain : B
UniProt : P48730 (KC1D_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.
ATP + [tau protein] = ADP + [tau protein] phosphate.