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Ligands
Code Name Style Show Link
C6Z 6-[(2,4-dichlorophenyl)methyl]pyridazine-3-thiol
GOL Glycerol
MG Magnesium ion
NA Sodium ion
SO4 Sulfate ion
ZN Zinc ion
Non-standard Residues
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Code : 6EZF   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : PDE2 in complex with molecule 5
Release Data : 2018-04-04
Compound :
mol_id molecule chains synonym
1 cGMP-dependent 3',5'-cyclic phosphodiesterase A Cyclic GMP-stimulated phosphodiesterase,cGSPDE
ec: 3.1.4.17
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
Authors : Tresadern, G., Perez-Benito, L., Keraenen, H., van Vlijmen, H.
Keywords : PDE2, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

Predicting Binding Free Energies of PDE2 Inhibitors. The Difficulties of Protein Conformation.

Perez-Benito, L.,Keranen, H.,van Vlijmen, H.  et al.
(2018)  Sci Rep  8 : 4883 - 4883

PubMed: 29559702
DOI: 10.1038/s41598-018-23039-5

Chain : A
UniProt : O00408 (PDE2A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'- phosphate + H(+) 3.1.4.17 PubMed:15938621, PubMed:29392776, PubMed:9210593
left-to-right PubMed:9210593
3',5'-cyclic GMP + H2O = GMP + H(+) - PubMed:15938621, PubMed:29392776, PubMed:9210593
left-to-right PubMed:9210593
3',5'-cyclic AMP + H2O = AMP + H(+) - PubMed:15938621, PubMed:29392776, PubMed:9210593
left-to-right PubMed:9210593