Het-PDB Navi2 (PDB: 6EYZ)

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Ligands
Code	Name		Style	Show	Link
C5W	2-methoxy-5-[4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]-1,3-oxazol-2-yl]-2~{H}-indazol-6-yl]pyridine-3-carboxylic acid				PoSSuM

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Download interaction data: 6EYZ

Code :

6EYZ PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

PI3 kinase delta in complex with 4-Fluorophenyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate

Release Data :

2017-12-20

Compound :

mol_id	molecule	chains
1	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Spodoptera frugiperda (taxid:7108)
	gene: Pik3cd

Authors :

Convery, M.A., Campos, S., Dalton, S.E.

Keywords :

Covalent inhibitor, kinase, drug discovery, complex, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

Selectively Targeting the Kinome-Conserved Lysine of PI3K delta as a General Approach to Covalent Kinase Inhibition.

Dalton, S.E.,Dittus, L.,Thomas, D.A. et al.
(2018) J. Am. Chem. Soc. 140 : 932 - 939

Chain :

UniProt :

Q3UDT3 (Q3UDT3_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+)	2.7.1.153	ARBA:ARBA00023981
	left-to-right	ARBA:ARBA00023981

PDB ID: 6EYZ