Het-PDB Navi2 (PDB: 6EXW)

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Ligands
Code	Name		Style	Show	Link
ZN	Zinc ion				PoSSuM
C3K	(3~{S},6~{S},7~{R},9~{a}~{S})-6-[[(2~{S})-2-(methylamino)propanoyl]amino]-5-oxidanylidene-~{N}-(phenylmethyl)-7-[(propanoylamino)methyl]-3,6,7,8,9,9~{a}-hexahydropyrrolo[1,2-a]azepine-3-carboxamide				PoSSuM

Non-standard Residues
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Download interaction data: 6EXW

Code :

6EXW PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN

Title :

Crystal structure of cIAP1-BIR3 in complex with a covalently bound SM

Release Data :

2018-08-08

Compound :

mol_id	molecule	chains	synonym
1	Baculoviral IAP repeat-containing protein 2	A,C	Cellular inhibitor of apoptosis 1,C-IAP1,IAP homolog B,Inhibitor of apoptosis protein 2,hIAP2,RING finger protein 48,RING-type E3 ubiquitin transferase BIRC2,TNFR2-TRAF-signaling complex protein 2
	ec: 2.3.2.27 fragment: Zinc-finger protein mutation: none

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: BIRC2, API1, MIHB, RNF48 expression_system_vector_type: plasmid expression_system_plasmid: pET28b

Authors :

Corti, A., Cossu, F., Milani, M., Mastrangelo, E.

Keywords :

Zinc finger motif, smac-mimetic, protein-ligand complex, BIR domain, signaling protein

Exp. method :

X-RAY DIFFRACTION ( 2.2000 Å )

Citation :

Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs.

Corti, A.,Milani, M.,Lecis, D. et al.
(2018) FEBS J. 285 : 3286 - 3298

Chain :

A, C

UniProt :

Q13490 (BIRC2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.	2.3.2.27	PubMed:18082613, PubMed:21145488, PubMed:21931591, PubMed:23453969
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PDB ID: 6EXW