Het-PDB Navi2 (PDB: 6EGD)

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Ligands
Code	Name		Style	Show	Link
J87	N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide				PoSSuM

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Download interaction data: 6EGD

Code :

6EGD PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor

Release Data :

2019-02-13

Compound :

mol_id	molecule	chains	synonym
1	Interleukin-1 receptor-associated kinase 4	D,A	IRAK-4,Renal carcinoma antigen NY-REN-64
	ec: 2.7.11.1 fragment: Protein kinase domain residues 164-460

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Trichoplusia ni (taxid:7111)
	gene: IRAK4 expression_system_common: Cabbage looper

Authors :

Ferrao, R., Wu, H.

Keywords :

Kinase, Unphosphorylated, Inactive, SIGNALING PROTEIN, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.100 Å )

Citation :

Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).

Wang, L.,Ferrao, R.,Li, Q. et al.
(2019) J.Biol.Chem. 294 : 4511 - 4519

Chain :

D, A

UniProt :

Q9NWZ3 (IRAK4_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.1	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.1	-
	-	-

PDB ID: 6EGD