Brand  (β version)

PDB ID: 6EGA

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Ligands
Code Name Style Show Link
J8A 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-B]pyridin-5-yl}-N-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide PoSSuM
SO4 Sulfate ion PoSSuM
CO Cobalt (II) ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6EGA   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : IRAK4 in complex with a type II inhibitor
Release Data : 2019-02-20
Compound :
mol_id molecule chains synonym
1 Interleukin-1 receptor-associated kinase 4 A,B IRAK-4,Renal carcinoma antigen NY-REN-64
ec: 2.7.11.1
fragment: Protein kinase domain residues 154-460
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: IRAK4
expression_system_common: Fall armyworm
Authors : Wang, L., Wu, H.
Keywords : Inhibitor, Complex, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.512 Å )
Citation :

Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).

Wang, L.,Ferrao, R.,Li, Q.  et al.
(2019)  J.Biol.Chem.  294 : 4511 - 4519

PubMed: 30679311
DOI: 10.1074/jbc.RA118.005428

Reaction

Chain : A, B
UniProt : Q9NWZ3 (IRAK4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 -
-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 -
-
Cofactor: Evidence: Note:
Mg(2+) - -