Brand  (β version)

PDB ID: 6EG3

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Ligands
Code Name Style Show Link
EOH Ethanol PoSSuM
J7G 3-[(4-{[(2-chloropyridin-4-yl)carbamoyl]amino}pyridin-2-yl)ethynyl]benzoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6EG3   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase Inhibitor
Title : Crystal structure of human BRM in complex with compound 15
Release Data : 2018-10-31
Compound :
mol_id molecule chains synonym
1 Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2 A MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
ec: 3.6.4.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SMARCA2, BAF190B, BRM, SNF2A, SNF2L2
Authors : Zhu, X., Kulathila, R., Hu, T., Xie, X.
Keywords : Helicase, ATPase, Chromatin remodeling, inhibitor, MBP fusion, Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.8400 Å )
Citation :

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.

Papillon, J.P.N.,Nakajima, K.,Adair, C.D.  et al.
(2018)  J. Med. Chem.  61 : 10155 - 10172

PubMed: 30339381
DOI: 10.1021/acs.jmedchem.8b01318

Reaction

Chain : A
UniProt : P0AEY0 (MALE_ECO57)
Reaction : -
Chain : A
UniProt : P51531 (SMCA2_HUMAN)
Reaction : -