Het-PDB Navi2 (PDB: 6EA8)

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Ligands
Code	Name		Style	Show	Link
J2A	(2s,5r,7r,8r,10r,12ar,14r,15r,15as,16r)-7-(2-amino-6-oxo-3,6-dihydro-9h-purin-9-yl)-14-(6-amino-9h-purin-9-yl)-15,16-dihydroxy-2,10-disulfanyloctahydro-2h,10h,12h-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-L][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione				PoSSuM

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Download interaction data: 6EA8

Code :

6EA8 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Structure of VACV poxin in pre-reactive state with nonhydrolyzable 2'3' cGAMP

Release Data :

2019-02-06

Compound :

mol_id	molecule	chains
1	Protein B2	A,B,C,D,E,F,G,H,I,J

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Vaccinia virus WR (taxid:10254)	VACV	Escherichia coli (taxid:562)
	strain: Western Reserve gene: VACWR184, B2R

Authors :

Eaglesham, J.B., Kranzusch, P.J.

Keywords :

Vaccina virus, nuclease, cGAS, cGAMP, poxvirus, innate immunity, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.600 Å )

Citation :

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.

Eaglesham, J.B.,Pan, Y.,Kupper, T.S. et al.
(2019) Nature 566 : 259 - 263

PDB ID: 6EA8