Brand  (β version)

PDB ID: 6EA2

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Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
GOL Glycerol PoSSuM
J1G N-[(1r)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]cyclopentanecarboxamide PoSSuM
MG Magnesium ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6EA2   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : X-ray crystal structure of Pf-M1 in complex with inhibitor (6h) and catalytic zinc ion
Release Data : 2018-12-26
Compound :
mol_id molecule chains synonym
1 M1 family aminopeptidase A Pfa-M1
ec: 3.4.11.-
fragment: UNP residues 195 to 1084
mutation: N213Q, N223Q, H378P, N501Q, N745Q, N795Q, N1069Q
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum (isolate FcB1 / Columbia)  (taxid:186763) Escherichia coli  (taxid:562)
strain: isolate FcB1 / Columbia
expression_system_strain: BL21
expression_system_vector_type: PTRCHIS-2B
Authors : Drinkwater, N., McGowan, S.
Keywords : M1 ALANYL-AMINOPEPTIDASE, PROTEASE, INHIBITOR, HYDROXAMIC ACID, HYDROLASE, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.3500 Å )
Citation :

Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.

Vinh, N.B.,Drinkwater, N.,Malcolm, T.R.  et al.
(2019)  J. Med. Chem.  62 : 622 - 640

PubMed: 30537832
DOI: 10.1021/acs.jmedchem.8b01310

Reaction

Chain : A
UniProt : O96935 (AMPN_PLAF7)
Reaction : -
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:12166515
ECO:0000269 | PubMed:19196988
ECO:0000269 | PubMed:21366301
Binds 1 zinc ion per subunit (PubMed:12166515, PubMed:19196988, PubMed:21366301, PubMed:21844374, PubMed:23713488, PubMed:23897806, PubMed:25299353, PubMed:25645579, PubMed:26406322, PubMed:26807544, PubMed:30537832, PubMed:32182520, Ref.21, Ref.24). Also, can use Mn(2+), Mg(2+) and Co(2+) with less efficiency (PubMed:12166515).