Brand  (β version)

PDB ID: 6E5Z

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
Non-standard Residues
Code Name Show
CCS Carboxymethylated cysteine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6E5Z   PDBj   RCSB PDB   PDBe
Header : hydrolase, UNKNOWN FUNCTION
Title : Crystal structure of human DJ-1 with a natural modification on Cys-106
Release Data : 2018-08-01
Compound :
mol_id molecule chains synonym
1 Protein/nucleic acid deglycase DJ-1 A Maillard deglycase,Oncogene DJ1,Parkinson disease protein 7,Parkinsonism-associated deglycase,Protein DJ-1,DJ-1
ec: 3.1.2.-,3.5.1.-,3.5.1.124
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PARK7
expression_system_variant: BL21(DE3) RIPL
expression_system_vector_type: pHisParallel
Authors : Shumilin, I.A., Shumilina, S.V., Minor, W.
Keywords : the exact function of this protein is still unknown, hydrolase, UNKNOWN FUNCTION
Exp. method : X-RAY DIFFRACTION ( 1.3500 Å )
Citation :

A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1.

Mussakhmetov, A.,Shumilin, I.A.,Nugmanova, R.  et al.
(2018)  Biochem. Biophys. Res. Commun.  504 : 328 - 333

PubMed: 30190129
DOI: 10.1016/j.bbrc.2018.08.190

Reaction

Chain : A
UniProt : Q99497 (PARK7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate 3.5.1.124 PubMed:25416785
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H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate 3.5.1.124 PubMed:25416785
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H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate 3.5.1.124 PubMed:25416785
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H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] = glycolate + H(+) + L-arginyl-[protein] 3.5.1.124 PubMed:25416785
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H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] = glycolate + H(+) + L-lysyl-[protein] 3.5.1.124 PubMed:25416785
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H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] = glycolate + H(+) + L-cysteinyl-[protein] 3.5.1.124 PubMed:25416785
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H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP = dGTP + H(+) + lactate - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP = GTP + H(+) + lactate - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP = GDP + H(+) + lactate - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP = GMP + H(+) + lactate - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP = dGTP + glycolate + H(+) - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP = glycolate + GTP + H(+) - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP = GDP + glycolate + H(+) - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP = glycolate + GMP + H(+) - PubMed:28596309
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an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O = a guanosine in RNA + H(+) + lactate - PubMed:28596309
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an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + H(+) + lactate - PubMed:28596309
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an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O = a guanosine in RNA + glycolate + H(+) - PubMed:28596309
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an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + glycolate + H(+) - PubMed:28596309
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