Brand  (β version)

PDB ID: 6DWE

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Ligands
Code Name Style Show Link
MLI Malonate ion PoSSuM
FMT Formic acid PoSSuM
P1T 2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]acrylic acid PoSSuM
CS Cesium ion PoSSuM
HDJ (2r,3s,4r)-3-(2',6'-difluoro-4'-methyl[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile PoSSuM
ACT Acetate ion PoSSuM
PGE Triethylene glycol PoSSuM
Non-standard Residues
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Structure summary

Code : 6DWE   PDBj   RCSB PDB   PDBe
Header : LYASE/LYASE INHIBITOR
Title : Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD0059-bound form
Release Data : 2018-07-11
Compound :
mol_id molecule chains
1 Tryptophan synthase alpha chain A,G,E,C
ec: 4.2.1.20
mol_id molecule chains
2 Tryptophan synthase beta chain B,H,F,D
ec: 4.2.1.20
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)  (taxid:83332) Escherichia coli BL21(DE3)  (taxid:469008)
strain: ATCC 25618 / H37Rv
gene: trpA, Rv1613, MTCY01B2.05
mol_id organism_scientific expression_system
2 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)  (taxid:83332) Escherichia coli BL21(DE3)  (taxid:469008)
strain: ATCC 25618 / H37Rv
gene: trpB, Rv1612, MTCY01B2.04
expression_system_vector_type: plasmid
expression_system_plasmid: pMCSG81
Authors : Chang, C., Michalska, K., Maltseva, N.I., Jedrzejczak, R., McCarren, P., Nag, P.P., Joachimiak, A., Satchell, K., Center for Structural Genomics of Infectious Diseases (CSGID)
Keywords : PLP, heterotetramer, amino acid biosynthesis, substrate channeling, allostery, Structural Genomics, Center for Structural Genomics of Infectious Diseases, CSGID, LYASE-LYASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.6910 Å )
Citation :

Crystal structure of tryptophan synthase from M. tuberculosis - closed form with BRD6309 bound

Chang, C.,Michalska, K.,Maltseva, N.I.  et al.
To be Published 

Reaction

Chain : A, G, E, C
UniProt : P9WFY1 (TRPA_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + L-tryptophan + H2O 4.2.1.20 HAMAP-Rule:MF_00131
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Chain : B, H, F, D
UniProt : P9WFX9 (TRPB_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + L-tryptophan + H2O 4.2.1.20 HAMAP-Rule:MF_00133
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Cofactor: Evidence: Note:
pyridoxal 5'-phosphate ECO:0000255 | HAMAP-Rule:MF_00133
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