Brand  (β version)

PDB ID: 6DJT

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Ligands
Code Name Style Show Link
FS0 Fe2/s3 cluster PoSSuM
GOL Glycerol PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
SF4 Iron/sulfur cluster PoSSuM
Non-standard Residues
Code Name Show
KPI (2s)-2-amino-6-[(1-hydroxy-1-oxo-propan-2-ylidene)amino]hexanoic acid
Glycosylation
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Structure summary

Code : 6DJT   PDBj   RCSB PDB   PDBe
Header : METAL BINDING PROTEIN
Title : Structure of TYW1 with a lysine-pyruvate adduct bound
Release Data : 2018-06-13
Compound :
mol_id molecule chains synonym
1 S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase A MjTYW1,tRNA wyosine derivatives biosynthesis protein Taw1
ec: 4.1.3.44
Source :
mol_id organism_scientific organism_common expression_system
1 Methanocaldococcus jannaschii  (taxid:2190) Methanococcus jannaschii Escherichia coli  (taxid:562)
gene: taw1, MJ0257
Authors : Grell, T.A.J., Drennan, C.L.
Keywords : S-Adenosylmethionine radical enzymes, tRNA biosynthetic enzyme, METAL BINDING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.640 Å )
Citation :

Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1.

Grell, T.A.J.,Young, A.P.,Drennan, C.L.  et al.
(2018)  J. Am. Chem. Soc.  140 : 6842 - 6852

PubMed: 29792696
DOI: 10.1021/jacs.8b01493

Reaction

Chain : A
UniProt : Q57705 (TYW1_METJA)
Reaction: EC: Evidence:
Physiological Direction:
N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl- L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine 4.1.3.44 HAMAP- Rule:MF_01921, PubMed:22026549
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