Brand  (β version)

PDB ID: 6D9X

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Ligands
Code Name Style Show Link
FZM 2-phenyl-6,7-dihydro-5h-pyrrolo[1,2-a]imidazole PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6D9X   PDBj   RCSB PDB   PDBe
Header : dna binding protein/inhibitor
Title : Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design
Release Data : 2018-09-05
Compound :
mol_id molecule chains synonym
1 WD repeat-containing protein 5 A BMP2-induced 3-kb gene protein
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: WDR5, BIG3
Authors : Phan, J., Fesik, S.W.
Keywords : WDR5, WIN-site, fragment screening, structure-based design, mixed-lineage leukemia, DNA BINDING PROTEIN, dna binding protein-inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.83 Å )
Citation :

Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.

Wang, F.,Jeon, K.O.,Salovich, J.M.  et al.
(2018)  J. Med. Chem.  61 : 5623 - 5642

PubMed: 29889518
DOI: 10.1021/acs.jmedchem.8b00375

Reaction

Chain : A
UniProt : P61964 (WDR5_HUMAN)
Reaction : -