Het-PDB Navi2 (PDB: 6D8E)

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Ligands
Code	Name		Style	Show	Link
FZP	(4-fluorophenyl)methyl {2-[(1-methyl-1h-pyrazol-3-yl)amino]pyrimidin-4-yl}[3-(propanoylamino)phenyl]carbamate				PoSSuM

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Download interaction data: 6D8E

Code :

6D8E PDBj RCSB PDB PDBe

Header :

Transferase/Transferase Inhibitor

Title :

Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor

Release Data :

2018-07-18

Compound :

mol_id	molecule	chains	synonym
1	Epidermal growth factor receptor	A	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
	ec: 2.7.10.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: EGFR, ERBB, ERBB1, HER1

Authors :

Park, E., Eck, M.J.

Keywords :

EGFR, Inhibitor, SIGNALING PROTEIN, Transferase-Transferase Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.537 Å )

Citation :

Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.

Jang, J.,Son, J.,Park, E. et al.
(2018) Angew. Chem. Int. Ed. Engl. 57 : 11629 - 11633

Chain :

UniProt :

P00533 (EGFR_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:15374980, PubMed:17349580, PubMed:18046415, PubMed:18227510, PubMed:19560417, PubMed:19563760
	-

PDB ID: 6D8E