PDB ID: 6D5M
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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FW4 | 1-[(3-chloro-4-fluorophenyl)methyl]-5,6-dimethyl-2-(piperazin-1-yl)-1h-benzimidazole | PoSSuM | |||
GNP | Phosphoaminophosphonic acid-guanylate ester | PoSSuM | |||
MG | Magnesium ion | PoSSuM |
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Download interaction data: 6D5M
Structure summary
Code : | 6D5M PDBj RCSB PDB PDBe | ||||||||||||||||||||||||||||||||||||
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Header : | SIGNALING PROTEIN | ||||||||||||||||||||||||||||||||||||
Title : | Ras:SOS:Ras in complex with a small molecule activator | ||||||||||||||||||||||||||||||||||||
Release Data : | 2018-09-19 | ||||||||||||||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Phan, J., Hodges, T., Fesik, S.W. | ||||||||||||||||||||||||||||||||||||
Keywords : | Ras, SOS, inhibitor, ONCOPROTEIN, Protein-protein complex, MAPK, SIGNALING PROTEIN | ||||||||||||||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.081 Å ) | ||||||||||||||||||||||||||||||||||||
Citation : |
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
Hodges, T.R.,Abbott, J.R.,Little, A.J.
et al.
PubMed: 30205005 Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Burns, M.C.,Sun, Q.,Daniels, R.N.
et al.
PubMed: 24550516 |
Reaction
Chain : | R | ||||||||
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UniProt : | P01112 (RASH_HUMAN) | ||||||||
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Chain : | S |
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UniProt : | Q07889 (SOS1_HUMAN) |
Reaction : | - |