Brand  (β version)

PDB ID: 6D20

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Ligands
Code Name Style Show Link
FQD 5-(4-fluorophenyl)thieno[2,3-D]pyrimidin-4(3h)-one PoSSuM
FQG 5-{[2,4-dichloro-5-(pyridin-2-yl)benzene-1-carbonyl]amino}-N-(2-hydroxy-2-methylpropyl)-1-phenyl-1h-pyrazole-3-carboxamide PoSSuM
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Structure summary

Code : 6D20   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/Inhibitor
Title : Crystal structure of Tyrosine-protein kinase receptor in complex with 5-(4-fluorophenyl)thieno[2,3-D]pyrimidin-4(3H)-one and 5-{[2,4-dichloro-5-(pyridin-2-yl)benzene-1-carbonyl]amino}-N-(2-hydroxy-2-methylpropyl)-1-phenyl-1H-pyrazole-3-carboxamide Inhibitors
Release Data : 2018-05-02
Compound :
mol_id molecule chains synonym
1 High affinity nerve growth factor receptor A Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA
ec: 2.7.10.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Insect cell expression vector pTIE1  (taxid:266783)
gene: NTRK1, MTC, TRK, TRKA
expression_system_vector_type: pKRIC-N6
Authors : Greasley, S.E., Johnson, E., Kraus, M.L., Cronin, C.N.
Keywords : Allosteric Inhibitor Complex Tyrosine kinase, TRANSFERASE, TRANSFERASE-Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.9400 Å )
Citation :

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors.

Bagal, S.K.,Omoto, K.,Blakemore, D.C.  et al.
(2019)  J. Med. Chem.  62 : 247 - 265

PubMed: 29672039
DOI: 10.1021/acs.jmedchem.8b00280

Reaction

Chain : A
UniProt : P04629 (NTRK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:1281417, PubMed:2927393
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