Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
ZN Zinc ion
FQV 4-[(but-2-yn-1-yl)selanyl]benzene-1-sulfonamide
GOL Glycerol
Code : 6D1L
Header : LYASE/LYASE INHIBITOR
Title : Design, synthesis, and X-ray of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects
Release Data : 2018-06-13
Compound :
mol_id molecule chains synonym
1 Carbonic anhydrase 2 A Carbonate dehydratase II, Carbonic anhydrase C, CAC, Carbonic anhydrase II, CA-II
ec: 4.2.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CA2
expression_system_vector_type: plasmid
expression_system_plasmid: pACA
Authors : Peat, T.S., Angeli, A., di Cesare Mannelli, L., Micheli, L., Ghelardini, C., Supuran, C.T.
Keywords : Carbonic Anhydrase Inhibitors, neuropathic pain, selenium, metalloenzymes, LYASE-LYASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.40 Å )
Citation :

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.

Angeli, A.,di Cesare Mannelli, L.,Lucarini, E.  et al.
(2018)  Eur J Med Chem  154 : 210 - 219

PubMed: 29803994
DOI: 10.1016/j.ejmech.2018.05.026

Chain : A
UniProt : P00918 (CAH2_HUMAN)
Reaction : H(2)CO(3) = CO(2) + H(2)O.