Het-PDB Navi2 (PDB: 6CZV)

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Ligands
Code	Name		Style	Show	Link
EDO	1,2-ethanediol				PoSSuM
FOY	1-benzyl-5-(3,5-dimethyl-1,2-oxazol-4-yl)pyridin-2(1h)-one				PoSSuM

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Download interaction data: 6CZV

Code :

6CZV PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION/INHIBITOR

Title :

BRD4(BD1) complexed with 2759

Release Data :

2018-09-26

Compound :

mol_id	molecule	chains	synonym
1	Bromodomain-containing protein 4	A	Protein HUNK1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: BRD4, HUNK1 expression_system_vector_type: Plasmid expression_system_plasmid: PJEXPRESS401

Authors :

Lakshminarasimhan, D., White, A., Suto, R.K.

Keywords :

BRD4(BD1), Bromodomain, TRANSCRIPTION-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.8800 Å )

Citation :

Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine.

Kharenko, O.A.,Patel, R.G.,Brown, S.D. et al.
(2018) J. Med. Chem. 61 : 8202 - 8211

PDB ID: 6CZV