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Ligands
Code Name Style Show Link
MG Magnesium ion
ARG Arginine
MPD (4s)-2-methyl-2,4-pentanediol
FSD Amicetin
ZN Zinc ion
SF4 Iron/sulfur cluster
Non-standard Residues
Code Name Show
PSU Pseudouridine-5'-monophosphate
5MU 5-methyluridine 5'-monophosphate
OMC O2'-methylycytidine-5'-monophosphate
5MC 5-methylcytidine-5'-monophosphate
OMG O2'-methylguanosine-5'-monophosphate
2MA 2-methyladenosine-5'-monophosphate
OMU O2'-methyluridine 5'-monophosphate
G7M N7-methyl-guanosine-5'-monophosphate
M2G N2-dimethylguanosine-5'-monophosphate
2MG 2n-methylguanosine-5'-monophosphate
4OC 4n,o2'-methylcytidine-5'-monophosphate
UR3 3-methyluridine-5'-monophoshate
MA6 6n-dimethyladenosine-5'-monophoshate
0TD (3s)-3-(methylsulfanyl)-L-aspartic acid
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 6CZR   PDBj   RCSB PDB   PDBe
Header : RIBOSOME/ANTIBIOTIC
Title : The structure of amicetin bound to the 70S ribosome
Release Data : 2019-04-10
Compound :
mol_id molecule chains
1 23S Ribosomal RNA 1A,2A
mol_id molecule chains
2 5S Ribosomal RNA 1B,2B
mol_id molecule chains
3 50S ribosomal protein L2 1D,2D
mol_id molecule chains
4 50S ribosomal protein L3 1E,2E
mol_id molecule chains synonym
5 50S ribosomal protein L4 1F,2F L1e
mol_id molecule chains
6 50S ribosomal protein L5 1G,2G
mol_id molecule chains
7 50S ribosomal protein L6 1H,2H
mol_id molecule chains
8 50S ribosomal protein L9 1I,2I
mol_id molecule chains
9 50S ribosomal protein L13 1N,2N
mol_id molecule chains
10 50S ribosomal protein L14 1O,2O
mol_id molecule chains
11 50S ribosomal protein L15 1P,2P
mol_id molecule chains
12 50S ribosomal protein L16 1Q,2Q
mol_id molecule chains
13 50S ribosomal protein L17 1R,2R
mol_id molecule chains synonym
14 50S ribosomal protein L18 1S,2S TL24
mol_id molecule chains
15 50S ribosomal protein L19 1T,2T
mol_id molecule chains
16 50S ribosomal protein L20 1U,2U
mol_id molecule chains
17 50S ribosomal protein L21 1V,2V
mol_id molecule chains
18 50S ribosomal protein L22 1W,2W
mol_id molecule chains
19 50S ribosomal protein L23 1X,2X
mol_id molecule chains
20 50S ribosomal protein L24 1Y,2Y
mol_id molecule chains synonym
21 50S ribosomal protein L25 1Z,2Z TL5
mol_id molecule chains
22 50S ribosomal protein L27 10,20
mol_id molecule chains
23 50S ribosomal protein L28 11,21
mol_id molecule chains
24 50S ribosomal protein L29 12,22
mol_id molecule chains
25 50S ribosomal protein L30 13,23
mol_id molecule chains
26 50S ribosomal protein L31 14,24
mol_id molecule chains
27 50S ribosomal protein L32 15,25
mol_id molecule chains
28 50S ribosomal protein L33 16,26
mol_id molecule chains
29 50S ribosomal protein L34 17,27
mol_id molecule chains
30 50S ribosomal protein L35 18,28
mol_id molecule chains synonym
31 50S ribosomal protein L36 19,29 Ribosomal protein B
mol_id molecule chains
32 16S Ribosomal RNA 1a,2a
mol_id molecule chains
33 30S ribosomal protein S2 1b,2b
mol_id molecule chains
34 30S ribosomal protein S3 1c,2c
mol_id molecule chains
35 30S ribosomal protein S4 1d,2d
mol_id molecule chains
36 30S ribosomal protein S5 1e,2e
mol_id molecule chains synonym
37 30S ribosomal protein S6 1f,2f TS9
mol_id molecule chains
38 30S ribosomal protein S7 1g,2g
mol_id molecule chains
39 30S ribosomal protein S8 1h,2h
mol_id molecule chains
40 30S ribosomal protein S9 1i,2i
mol_id molecule chains
41 30S ribosomal protein S10 1j,2j
mol_id molecule chains
42 30S ribosomal protein S11 1k,2k
mol_id molecule chains
43 30S ribosomal protein S12 1l,2l
mol_id molecule chains
44 30S ribosomal protein S13 1m,2m
mol_id molecule chains
45 30S ribosomal protein S14 type Z 1n,2n
mol_id molecule chains
46 30S ribosomal protein S15 1o,2o
mol_id molecule chains
47 30S ribosomal protein S16 1p,2p
mol_id molecule chains
48 30S ribosomal protein S17 1q,2q
mol_id molecule chains
49 30S ribosomal protein S18 1r,2r
mol_id molecule chains
50 30S ribosomal protein S19 1s,2s
mol_id molecule chains
51 30S ribosomal protein S20 1t,2t
mol_id molecule chains synonym
52 30S ribosomal protein Thx 1u,2u S31
Source :
mol_id organism_scientific
1 Thermus thermophilus HB8  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
2 Thermus thermophilus HB8  (taxid:300852)
mol_id organism_scientific
3 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
4 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
5 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
6 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
7 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
8 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
9 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
10 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
11 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
12 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
13 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
14 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
15 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
16 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
17 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
18 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
19 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
20 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
21 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
22 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
23 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
24 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
25 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
26 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
27 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
28 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
29 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
30 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
31 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
32 Thermus thermophilus HB8  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
33 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
34 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
35 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
36 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
37 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
38 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
39 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
40 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
41 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
42 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
43 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
44 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
45 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
46 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
47 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
48 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
49 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
50 Thermus thermophilus  (taxid:300852)
mol_id organism_scientific
51 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
mol_id organism_scientific
52 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)  (taxid:300852)
strain: HB8 / ATCC 27634 / DSM 579
Authors : Eiler, D.R., Steitz, T.A., Looper, R.E., Serrano, C.M., Kannareddy, H.R., Koch, M.R., Barrows, L.R., Testa, C.A., Sebahar, P.R.
Keywords : 70S ribosome, amicetin, antibiotic complex, translation, RIBOSOME-ANTIBIOTIC complex
Exp. method : X-RAY DIFFRACTION ( 3.1400 Å )
Citation :

Unifying the Aminohexopyranose- and Peptidyl-Nucleoside Antibiotics: Implications for Antibiotic Design

Serrano, C.M.,Kanna Reddy, H.R.,Eiler, D.R.  et al.
(2020)  Angew.Chem.Int.Ed.Engl.  132 : 11426 - 11429

DOI: 10.1002/ange.202003094

Chain : 1D, 2D
UniProt : P60405 (RL2_THET8)
Reaction : -
Chain : 1E, 2E
UniProt : Q5SHN8 (RL3_THET8)
Reaction : -
Chain : 1F, 2F
UniProt : Q5SHN9 (RL4_THET8)
Reaction : -
Chain : 1G, 2G
UniProt : Q5SHQ0 (RL5_THET8)
Reaction : -
Chain : 1H, 2H
UniProt : P0DOY8 (RL6_THET8)
Reaction : -
Chain : 1I, 2I
UniProt : Q5SLQ1 (RL9_THET8)
Reaction : -
Chain : 1N, 2N
UniProt : P60488 (RL13_THET8)
Reaction : -
Chain : 1O, 2O
UniProt : Q5SHP8 (RL14_THET8)
Reaction : -
Chain : 1P, 2P
UniProt : Q5SHQ7 (RL15_THET8)
Reaction : -
Chain : 1Q, 2Q
UniProt : P60489 (RL16_THET8)
Reaction : -
Chain : 1R, 2R
UniProt : Q9Z9H5 (RL17_THET8)
Reaction : -
Chain : 1S, 2S
UniProt : Q5SHQ4 (RL18_THET8)
Reaction : -
Chain : 1T, 2T
UniProt : P60490 (RL19_THET8)
Reaction : -
Chain : 1U, 2U
UniProt : P60491 (RL20_THET8)
Reaction : -
Chain : 1V, 2V
UniProt : P60492 (RL21_THET8)
Reaction : -
Chain : 1W, 2W
UniProt : Q5SHP3 (RL22_THET8)
Reaction : -
Chain : 1X, 2X
UniProt : Q5SHP0 (RL23_THET8)
Reaction : -
Chain : 1Y, 2Y
UniProt : Q5SHP9 (RL24_THET8)
Reaction : -
Chain : 1Z, 2Z
UniProt : Q5SHZ1 (RL25_THET8)
Reaction : -
Chain : 10, 20
UniProt : P60493 (RL27_THET8)
Reaction : -
Chain : 11, 21
UniProt : P60494 (RL28_THET8)
Reaction : -
Chain : 12, 22
UniProt : Q5SHP6 (RL29_THET8)
Reaction : -
Chain : 13, 23
UniProt : Q5SHQ6 (RL30_THET8)
Reaction : -
Chain : 14, 24
UniProt : Q5SJE1 (RL31_THET8)
Reaction : -
Chain : 15, 25
UniProt : P80339 (RL32_THET8)
Reaction : -
Chain : 16, 26
UniProt : P35871 (RL33_THET8)
Reaction : -
Chain : 17, 27
UniProt : P80340 (RL34_THET8)
Reaction : -
Chain : 18, 28
UniProt : Q5SKU1 (RL35_THET8)
Reaction : -
Chain : 19, 29
UniProt : Q5SHR2 (RL36_THET8)
Reaction : -
Chain : 1b, 2b
UniProt : P80371 (RS2_THET8)
Reaction : -
Chain : 1c, 2c
UniProt : P80372 (RS3_THET8)
Reaction : -
Chain : 1d, 2d
UniProt : P80373 (RS4_THET8)
Reaction : -
Chain : 1e, 2e
UniProt : Q5SHQ5 (RS5_THET8)
Reaction : -
Chain : 1f, 2f
UniProt : Q5SLP8 (RS6_THET8)
Reaction : -
Chain : 1g, 2g
UniProt : P17291 (RS7_THET8)
Reaction : -
Chain : 1h, 2h
UniProt : P0DOY9 (RS8_THET8)
Reaction : -
Chain : 1i, 2i
UniProt : P80374 (RS9_THET8)
Reaction : -
Chain : 1j, 2j
UniProt : Q5SHN7 (RS10_THET8)
Reaction : -
Chain : 1k, 2k
UniProt : P80376 (RS11_THET8)
Reaction : -
Chain : 1l, 2l
UniProt : Q5SHN3 (RS12_THET8)
Reaction : -
Chain : 1m, 2m
UniProt : P80377 (RS13_THET8)
Reaction : -
Chain : 1n, 2n
UniProt : P0DOY6 (RS14Z_THET8)
Reaction : -
Chain : 1o, 2o
UniProt : Q5SJ76 (RS15_THET8)
Reaction : -
Chain : 1p, 2p
UniProt : Q5SJH3 (RS16_THET8)
Reaction : -
Chain : 1q, 2q
UniProt : P0DOY7 (RS17_THET8)
Reaction : -
Chain : 1r, 2r
UniProt : Q5SLQ0 (RS18_THET8)
Reaction : -
Chain : 1s, 2s
UniProt : Q5SHP2 (RS19_THET8)
Reaction : -
Chain : 1t, 2t
UniProt : P80380 (RS20_THET8)
Reaction : -
Chain : 1u, 2u
UniProt : Q5SIH3 (RSHX_THET8)
Reaction : -