Het-PDB Navi2 (PDB: 6CZ5)

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Ligands
Code	Name		Style	Show	Link
FPJ	5'-O-[(R)-hydroxy(propanoylamino)phosphoryl]adenosine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6CZ5

Code :

6CZ5 PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal structure of small molecule AMP-acrylamide covalently bound to DDX3 S228C

Release Data :

2018-08-08

Compound :

mol_id	molecule	chains	synonym
1	ATP-dependent RNA helicase DDX3X	A	DEAD box protein 3, X-chromosomal, DEAD box, X isoform, Helicase-like protein 2, HLP2
	ec: 3.6.4.13 fragment: UNP residues 132-607 mutation: S228C

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: DDX3X, DBX, DDX3

Authors :

Barkovich, K.J., Moore, M.K., Hu, Q., Shokat, K.M.

Keywords :

Inhibitor, DEAD-box protein, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 3.0000 Å )

Citation :

Chemical genetic inhibition of DEAD-box proteins using covalent complementarity.

Barkovich, K.J.,Moore, M.K.,Hu, Q. et al.
(2018) Nucleic Acids Res. 46 : 8689 - 8699

Chain :

UniProt :

O00571 (DDX3X_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + H2O = ADP + H(+) + phosphate	3.6.4.13	PubMed:15507209, PubMed:17357160, PubMed:21589879, PubMed:31300642, PubMed:31575075
ATP + H2O = ADP + H(+) + phosphate	-

PDB ID: 6CZ5