Brand  (β version)

PDB ID: 6CZ3

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
FLJ (3-fluoro-4-{[6-methyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone PoSSuM
K Potassium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6CZ3   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase Inhibitor
Title : Structure of the PTK6 kinase domain bound to a type I inhibitor (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone
Release Data : 2018-06-20
Compound :
mol_id molecule chains synonym
1 Protein-tyrosine kinase 6 A Breast tumor kinase,Tyrosine-protein kinase BRK
ec: 2.7.10.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PTK6, BRK
Authors : Gajiwala, K.S., Johnson, E., Cronin, C.N.
Keywords : Protein kinase, PTK6, Transferase-Transferase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.

Qiu, L.,Levine, K.,Gajiwala, K.S.  et al.
(2018)  PLoS ONE  13 : e0198374 - e0198374

PubMed: 29879184
DOI: 10.1371/journal.pone.0198374

Reaction

Chain : A
UniProt : Q13882 (PTK6_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:12121988, PubMed:27480927, PubMed:27993680
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